GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs1474698 | 1 | rs9296832 | chr6:56100909 | COL21A1 | chr6:55921389-56258892:- | 0.36 | 6.58 | 1.54E-10 | Pulse pressure |
| BLCA | cis | rs929843 | 1 | rs929843 | chr16:70045748 | CLEC18A | chr16:69984626-69997887:+ | -0.39 | -5.16 | 3.88E-7 | Menarche (age at onset) |
| BLCA | cis | rs929843 | 1 | rs929843 | chr16:70045748 | PDXDC2 | chr16:70010210-70099851:- | -0.24 | -4.67 | 4.08E-6 | Menarche (age at onset) |
| BLCA | cis | rs9303401 | 1 | rs9303401 | chr17:56847945 | RAD51C | chr17:56769963-56811690:+ | 0.29 | 5.15 | 4.09E-7 | Cognitive test performance |
| BLCA | cis | rs2273 | 1 | rs9307050 | chr4:76905649 | NAAA | chr4:76831809-76862166:- | -0.39 | -6.41 | 4.28E-10 | Longevity |
| BLCA | cis | rs9309473 | 1 | rs9309473 | chr2:73743982 | ALMS1P | chr2:73872046-73912692:+ | 0.35 | 5.15 | 4.19E-7 | Metabolite levels |
| BLCA | cis | rs7714584 | 1 | rs931058 | chr5:150333698 | LOC134466 | chr5:150310000-150326146:- | 0.68 | 7.36 | 1.15E-12 | Crohn's disease |
| BLCA | cis | rs9815354 | 1 | rs9311288 | chr3:41804581 | ULK4 | chr3:41288091-42003660:- | 0.63 | 9.7 | 4.95E-20 | Diastolic blood pressure |
| BLCA | cis | rs9311676 | 1 | rs9311676 | chr3:58470351 | PDHB | chr3:58413355-58419565:- | -0.24 | -3.9 | 0.000114 | Systemic lupus erythematosus |
| BLCA | cis | rs1417205 | 1 | rs9316278 | chr13:47841469 | ESD | chr13:47345392-47371367:- | 0.36 | 4.26 | 2.58E-5 | Cannabis use (initiation) |
| BLCA | cis | rs1417205 | 1 | rs9316278 | chr13:47841469 | SUCLA2 | chr13:48516792-48612125:- | 0.38 | 4.47 | 1.04E-5 | Cannabis use (initiation) |
| BLCA | cis | rs9318086 | 1 | rs9318086 | chr13:24432467 | PCOTH | chr13:24463028-24466241:+ | 0.28 | 4.26 | 2.56E-5 | Myopia (pathological) |
| BLCA | cis | rs9322193 | 1 | rs9322193 | chr6:149919143 | NUP43 | chr6:150045453-150067688:- | -0.28 | -4.52 | 8.44E-6 | Lung cancer |
| BLCA | cis | rs7714584 | 1 | rs9324660 | chr5:150257054 | LOC134466 | chr5:150310000-150326146:- | 0.46 | 5.96 | 5.61E-9 | Crohn's disease |
| BLCA | cis | rs9457247 | 1 | rs932644 | chr6:167404187 | RNASET2 | chr6:167343008-167412795:- | -0.25 | -5.15 | 4.08E-7 | Crohn's disease |